Simons Foundation

Research

The environment of NGG 1277

Astronomical Data The Astronomical Data group develops, maintains and propagates advanced methods and open-source tools for the astrophysics community, especially for building probabilistic models, discovering sources in noisy data and making precise measurements. It builds these methods and tools by carrying out in-house data analysis projects that answer important scientific questions. It also hosts events and workshops that are designed to create new data analysis opportunities for members of the astronomical community.

Biological Transport Networks The Biological Flow Networks Group employs theoretical and computational methodologies to elucidate the underlying principles governing the evolution, development and functionality of biological flow networks, such as arterial, venous, and lymphatic systems and biological transport systems in general.

Biomolecular Design The theory of protein folding explains how a disordered chain of amino acids spontaneously adopts a well-defined three-dimensional structure in water. The ultimate test of a theory is its successful application to the design of new physical systems with new, desired properties. In the Biomolecular Design Group, we apply the theory of protein folding to design new heteropolymers that fold into well-defined three-dimensional structures with new, useful functions, but which are built from exotic chemical building-blocks that go beyond the 20 canonical amino acids that make up natural proteins.

Digital image of dynamics of complex and active materials

Biophysical Modeling The Biophysical Modeling group focuses on the modeling and simulation of complex systems that arise in biology and soft condensed matter physics. Areas of interest include the dynamics of complex and active materials, as well as aspects of collective behavior and self-organization in both natural systems (e.g., inside the cell) and synthetic ones.

Computational Vision We are interested in the analysis and representation of visual information, including empirical study of the structure of visual scenes, construction of mathematical theories for representation and processing that structure.

Cosmology Researchers at the Center for Computational Astrophysics (CCA) stand at the forefront of advancing our understanding of the universe by melding cutting-edge machine learning and data science techniques with profound cosmological inquiries. In an era where cosmology is undergoing a transformative shift, this group spearheads the development of pioneering algorithms and innovative conceptual frameworks that are tailored to the increasingly complex cosmological datasets. Harnessing the collective power of ground-based and space-based telescopes furnished with progressively sensitive cameras and instruments, researchers at CCA are at the vanguard of endeavors such as SDSS, Vera Rubin Observatory, Euclid, SPHEREX, HIRAX and Roman Space Telescope.

Image of genomic instructions and self-organizing physical mechanisms to embryonic development

Developmental Dynamics The Developmental Dynamics group combines experiments, theory and computing to elucidate the contributions of encoded genomic instructions and self-organizing physical mechanisms to embryonic development.

Digital illustration of Quantum physics with hourglass cones and swirls

Dynamics and Control At the Center for Computational Quantum Physics, we are developing the conceptual basis, theoretical formalism and computational tools needed to use the quantum nature of light to understand and control quantum phenomena in complex systems.

Exoplanets Exoplanet researchers at the Center for Computational Astrophysics (CCA) study the origins and evolution of planetary systems around other stars, from simulations of their initial formation to observations of their present-day conditions.

Digital illustration of galaxy formation

Galaxy Formation The Galaxy Formation group is developing the numerical tools and physical insights necessary to understand how galaxies form and evolve within a cosmological context.

Graphic of a genome-wide scale functional interaction network overlaid on a brain

Genomics An immensely complex molecular network of interactions forms the foundation of human biology and disease. Genomic approaches provide a particularly illuminating window to biological systems, and when combined with advanced analysis allow us to learn and model this complexity.

Graphs of recovered gravitational waveforms. The dark band shows estimates for the waveform without assuming a particular source. The light bands show results if we assume it is a binary black hole (BBH) as predicted by general relativity. They match really well

Gravitational Wave Astronomy The detection of gravitational waves from the merging binary black hole GW150914, followed by the (likely) binary black hole mergers LVT151012, GW151226, and GW170104, means the era of gravitational wave astronomy is upon us.

Reconstruction of a symmetric protein from cryo electron microscopy data

Image and Signal Processing At CCM, we develop new computational and statistical methods, and accompanying software, for the analysis of large, complex data sets, especially those that arise from high-throughput scientific experiments.

Initiative for Computational Catalysis The Simons Foundation Initiative for Computational Catalysis is a new effort within the Flatiron Institute dedicated to the development and application of computational techniques enabling the rational design of more efficient and more affordable catalysts.

Machine Learning X Astrophysics Machine learning is being increasingly integrated into scientific discovery to augment and accelerate research, helping scientists to generate hypotheses, design experiments, collect and interpret large datasets, and gain insights that might not have been possible using traditional scientific methods alone. Researchers at CCA is leading the wave of rapid development and adoption of machine learning techniques to enable and accelerate scientific discovery.

Nearby Universe The Nearby Universe group studies the structure, growth and dynamical evolution of our galaxy and its neighbors. We use the nearby universe as a laboratory to constrain dynamical processes and the properties of dark matter. The group works at the interface between large observed and simulated datasets.

A complex diagram incorporating representations of neurons.

Neural Circuits and Algorithms Our goal is to understand how the brain analyzes large and complex datasets streamed by sensory organs in order to aid efforts at building artificial neural systems and treating mental illness.

A diagram incorporating a line graph and organic 3-D shapes.

NeuroAI and Geometric Data Analysis Our group develops mathematical theories for understanding how neurons collectively give rise to behavior in biological and artificial neural networks. Our current focus is on addressing this question through two broad approaches at the intersection of computational neuroscience and deep learning:

Numerical Analysis The direct numerical simulation of many scientific processes remains impractical, even with modern supercomputers.

Colorful digital illustration of quantum materials

Quantum Materials What arrangement produces a material with an optimal thermoelectric figure of merit, or a combination of magnetic and ferroelectric properties, or a high superconducting critical temperature?

Image of code that reads:

Software Libraries A major effort of the CCQ is the development and support of high quality open-source software for quantum many-body physics research. Making software which is reliable, efficient, and productive accelerates discovery and fosters scientific consensus and reproducibility.

Stars and Plasma Astrophysics The Stars & Plasma Astrophysics (SPA) Group is dedicated to developing the theoretical framework and computational methods necessary to investigate the life and death of stars, as well as the astrophysics of neutron stars and black holes. The group’s goal is to enhance our understanding of the physics of stars, their explosive deaths and the compact remnants they leave behind. To achieve this goal, we develop theoretical and computational models of stars and stellar explosions, as well as plasma in extreme conditions, that can be tested by new observations.

Statistical Analysis of Neural Data We develop statistical models and open-source computational tools to extract insights from neural data. We are particularly interested in characterizing flexibility and variability in neural circuits—e.g., how do the dynamics of large neural ensembles change over the course of learning a new skill, during periods of high attention or task engagement, or during development and aging.

Digital illustration of quantum many-body problem

Theory and Methods The quantum many-body problem is one of the hard problems of complexity theory: A direct solution requires computational resources that grow exponentially with the size of the problem to be solved.